Physics 7715: Biomedical Optics
Fundamental concepts in optics and spectroscopy and to acquire basic skills for modeling and experimental research in selected biomedical applications.
This is a research-oriented course on diverse topics in
biomedical optics with a team teaching approach. The course will be divided
into four modules with each instructor covering a set of subjects most relevant
to their research interests. Attendance is required and homework problems will
be handed out during each module to prepare students for the module exams. No
score will be given for homework turned in after the deadline. Each instructor
will give a 75-minute exam at the last lecture of the module. In general, the
homework and exam scores contribute 40% and 60%, respectively, to the combined
score. At the end of the semester, the grades for each module, normalized to 40
points for Dr. Hu’s module and 20 points for the other three modules, will be
summed to yield a final letter grade based on: ³ 90 = A; ³ 80
& < 90 = B; ³
70 & < 80 = C; < 70 = F.
13:00 – 14:15 MW, Howell Science Complex (HSC) E213
(Some meetings of the class may be mover to HSC E201)
Final Examination: 11:00 - 13:30 Wednesday, December 12 (Student presentations of research proposals for extra credit.)
|
Dr. Xin-Hua Hu |
Howell Science Complex: C203 |
hux@ecu.edu |
|
Dr. John Kenney |
Science and Technology: 504 |
kenneyJ@ecu.edu |
|
Dr. Yong-Qing Li |
Austin 115 |
liy@ecu.edu |
|
Dr. John Sutherland |
Howell Science Complex: C209 |
sutherlandj@ecu.edu |
Biomedical Optics: Principles and Imaging, Wang and Wu (available
from Amazon.com)
|
Sutherland |
Introduction to biomedical optics: Regions of the “optical” spectrum (visible, ultraviolet, near infrared, infrared), light sources (black bodies, spectral lines, lasers, synchrotron radiation), monochromators & spectrographs (prism and gratings), detectors (photomultipliers and solid state detectors), an overview of the interactions of light with matter (scattering, resonant and Raman; absorption (vibrational and electronic); luminescence (fluorescence, phosphorescence, delayed fluorescence), photochemistry, polarization dependent spectroscopies and the photoelastic modulator (CD, MCD, LD, FPA) |
August 22 (no test) |
|
Hu |
Wave Optics and Elastic Light Scattering: Maxwell equations and wave equations; wave propagation and mode; lasers; light-medium interaction; light scattering and polarization, Stokes vectors and Mueller matrix; modeling of light scattering; Mie theory; elastic light scattering by cells |
August 22, 29 September 4, 5, 10, 12, 17, 19, 24, 26 (exam) |
|
Sutherland |
Electronic and vibrational absorption spectroscopy; Emission Spectroscopy; Photochemistry of proteins and nucleic acids; introduction to the physics of polarization-dependent spectroscopies in absorption and emission: circular dichroism, magnetic circular dichroism, linear dichroism, fluorescence polarization anisotropy |
October 1, 3, 10, 15, 17, 22 (exam) |
|
Kenney |
Biomedical
Applications of Circular Dichroism and Related Spectroscopies |
October 24, 29, 31 |
|
Li |
Optical Tweezers, Raman Spectroscopy, multi-photon spectroscopy: basic theory of Raman scattering and optical trapping; instrumentation and experimental techniques; Raman tweezers; nonlinear Raman spectroscopy; multiphoton microscopy; biomedical applications. |
November 12, 14, 19, 26, 28 December 3 (exam) |
Wireless Policy: Unless specifically authorized by the instructor, all wireless devices {computers, tablet computers, mobile phones, etc.} must be deactivated during all Department of Physics Classes.
ADA Statement: East Carolina University seeks to comply fully with the Americans with Disabilities Act (ADA). Students requesting accommodations based on a disability must be registered with the Department for Disability Support Services located in Slay 138 ((252) 737-1016 (Voice/TTY)).
PHYSICS 7715: Biomedical
Optics
Optical Tweezers, Raman Spectroscopy, multi-photon
spectroscopy
1.
Course Web: http://core.ecu.edu/phys/liy/phys7715/
Schedule
|
Nov. 12 M |
Optical trapping (I): Lecture
Note (ppt) reference 1, reference 2, reference
3, reference 4, reference 5 |
|
|
Nov. 14 W |
Optical trapping (II): |
|
|
Nov. 19 M |
Raman spectroscopy: Lecture
Note (ppt) reference 1, reference 2, reference
3, reference 4, reference 5 |
|
|
Nov. 21 W (no class) |
|
|
|
Nov. 26 M |
Raman imaging: Lecture Note
(ppt) reference 1, reference 2, reference
3, reference 4, reference 5 |
|
|
Nov. 28 W |
Multiphoton
microscopy & super-resolution
microscopy: Lecture Note (ppt), reference 1, reference
2, reference 3, reference 4, reference 5 |
|
|
Dec. 3 M (exam) |
|
2. Homework/Exam (due December 3, 2012)
Read & search the relevant references. Select one topic listed below. Write a review article (10-15 pages) that review the recent research progress of the field in this topic, including all the references. The potential topics include:
(1) The biomedical application of optical tweezers;
(2) The biomedical application of Raman spectroscopy (or a specific technique) in cancer or medical diagnosis;
(3) The applications of Raman spectroscopy (or a specific technique) in biology and biochemistry;
(4) The biomedical applications of multiphoton confocal microscopy or super-resolution microscopy.
Homework - Each student will have a presentation in class (20 min presentation + 10 min discussion); 40%
Exam – Each student will turn in a hard copy of your review article for grading. 60%