Slide 61 of 62
Notes:
Proteosome, not membrane bound, but complex like a ribosome.
700 kD from bacteria T. acidophilium--20S, four stacked rings, a7b7b7a7 (a is red)
1.3 nm opening in the outer a7 rings controls entry
B subunits possess proteolytic activity
Product of proteosome degradation are 7-9 aa long
Eucaryotes have 20S and 26S proteosomes
