Eukaryotic Initiation

Slide 34 of 62

Notes:

Ternary complex excludes the mRNA.

eIF is nomenclature.

Three fundamental steps

1) Preinitiation complex formation: 43S

2) Binding of 43S complex with mRNA: uses eIF4A, B, E, G: 48S

Then scanning to find AUG

3) Addition of 60S subunit to make 80S initiation complex: translation occurs